SCHEMBL26455116

SCHEMBL26455116

Cc1cn([C@@H]2C[C@@H]3[C@H](O2)[C@H](OP(C)OCCC#N)C[C@H]3C)c(=O)nc1NC(=O)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.36
▸ ABL1 P00519 1/20 0.34
▸ RIN1 Q13671 1/20 0.34
▸ RNASE1 P07998 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26455085 0.94 POLB (0.36) POLBABL1RIN1RNASE1
SCHEMBL26455123 0.83 P2RY12 (0.38) —
SCHEMBL26455112 0.79 ABL1 (0.40) POLBABL1RIN1RNASE1
SCHEMBL26455083 0.77 ABL1 (0.42) POLBABL1RIN1RNASE1
SCHEMBL25504711 0.76 POLB (0.46) POLBABL1RIN1RNASE1
SCHEMBL18503734 0.76 ABL1 (0.32) ABL1RIN1
SCHEMBL18708173 0.76 ABL1 (0.32) ABL1RIN1
SCHEMBL26455110 0.76 TK1 (0.41) RNASE1
SCHEMBL2695113 0.76 CYP1A2 (0.33) POLBABL1RIN1
SCHEMBL14702196 0.75 ABL1 (0.32) ABL1RIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230132377-A9 OLIGONUCLEOTIDES CONJUGATES COMPRISING 7'-5'-ALPHA-ANOMERIC-BICYCLIC SUGAR NUCLEOSIDES ALPHA ANOMERIC SAS (FR) 2023-04-27 — — US disclosed
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