Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.39 |
| ▸ | CBFB | Q13951 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.35 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2645922 | 0.89 | CBFB (0.52) | CBFBGRM5ALDH1A1SMN1; SMN2 | |
| SCHEMBL2646501 | 0.88 | CBFB (0.41) | CHEK2CYP19A1FFAR4CBFBGRM5 | |
| SCHEMBL2644929 | 0.88 | CHEK2 (0.41) | CHEK2CYP19A1FFAR4CBFBLMNA | |
| SCHEMBL2646787 | 0.86 | CBFB (0.40) | CHEK2CYP19A1FFAR4CBFBGRM5 | |
| SCHEMBL2646752 | 0.84 | CHEK2 (0.36) | CHEK2CYP19A1FFAR4CBFBLMNA | |
| SCHEMBL2643874 | 0.84 | CYP19A1 (0.42) | CHEK2CYP19A1FFAR4LMNATDP1 | |
| SCHEMBL2646329 | 0.84 | CYP2E1 (0.38) | CHEK2CYP19A1FFAR4CBFBGRM5 | |
| SCHEMBL2645624 | 0.84 | CHEK2 (0.38) | CHEK2CYP19A1FFAR4CBFBGRM5 | |
| SCHEMBL2645975 | 0.83 | CYP19A1 (0.40) | CHEK2CYP19A1FFAR4GRM5LMNA | |
| SCHEMBL2645371 | 0.83 | CBFB (0.38) | CHEK2CYP19A1FFAR4CBFBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1702919-B1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | MSD KK (JP) | 2012-05-30 | — | — | EP | disclosed |
| EP-1702919-A1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-09-20 | — | — | EP | disclosed |