Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2642101 | 0.88 | HPGD (0.47) | HPGDGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL2647252 | 0.84 | FGFR1 (0.62) | HPGDGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL2656192 | 0.84 | IDO1 (0.49) | HPGDIDO1FGFR1NCOA3CYP3A4 | |
| SCHEMBL28522776 | 0.81 | IDO1 (0.49) | IDO1NCOA3CYP3A4ALDH1A1 | |
| SCHEMBL2660149 | 0.81 | FGFR1 (0.45) | HPGDIDO1FGFR1NCOA3CYP3A4 | |
| SCHEMBL2646511 | 0.81 | HPGD (0.47) | HPGDIDO1FGFR1NCOA3CYP3A4 | |
| SCHEMBL20510883 | 0.81 | FGFR1 (0.58) | IDO1FGFR1CYP3A4 | |
| SCHEMBL2646699 | 0.80 | KDR (0.54) | HPGDIDO1FGFR1CYP3A4ALDH1A1 | |
| SCHEMBL13618142 | 0.79 | FGFR1 (0.65) | FGFR1ALDH1A1 | |
| SCHEMBL2653789 | 0.79 | IDO1 (0.42) | HPGDIDO1FGFR1NCOA3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0616807-B1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH AS (DK) | 1998-07-08 | — | — | EP | claimed |
| US-5554630-A | TREATING ANXIETY, CONVULSIONS AND SLEEP DISORDERS IN LIVING ANIMALS BY MODULATION OF THE BENZODIAZEPINE RECEPTOR OF THE CENTRAL NERVOUS SYSTEM WITH 1-/3-HETEROCYCLYLPHENYL/-BENZIMIDAZOLES | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | claimed |
| EP-0616807-A1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH A/S (DK) | 1994-09-28 | — | — | EP | claimed |
| EP-0616807-B1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH AS (DK) | 1998-07-08 | — | — | EP | disclosed |
| US-5554632-A | CENTRAL NERVOUS SYSTEM | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| US-5554630-A | TREATING ANXIETY, CONVULSIONS AND SLEEP DISORDERS IN LIVING ANIMALS BY MODULATION OF THE BENZODIAZEPINE RECEPTOR OF THE CENTRAL NERVOUS SYSTEM WITH 1-/3-HETEROCYCLYLPHENYL/-BENZIMIDAZOLES | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| EP-0616807-A1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH A/S (DK) | 1994-09-28 | — | — | EP | disclosed |