Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646728 | 0.85 | FGFR1 (0.69) | FGFR1ALDH1A1HPGDMAPTHTT | |
| SCHEMBL2646173 | 0.84 | FGFR1 (0.50) | FGFR1ALDH1A1HPGDMAPTPDE10A | |
| SCHEMBL12818000 | 0.75 | FGFR1 (0.48) | FGFR1ALDH1A1HPGDMAPTPDE10A | |
| SCHEMBL2645883 | 0.74 | KDM4E (0.42) | FGFR1ALDH1A1HPGDMAPTHTT | |
| SCHEMBL2306019 | 0.72 | FGFR1 (0.67) | FGFR1ALDH1A1HTT | |
| SCHEMBL2951988 | 0.72 | PDE10A (0.47) | FGFR1ALDH1A1MAPTPDE10AHTT | |
| SCHEMBL28194847 | 0.72 | PDE10A (0.47) | FGFR1ALDH1A1MAPTPDE10AHTT | |
| SCHEMBL7472806 | 0.70 | PDE10A (0.45) | FGFR1ALDH1A1MAPTPDE10AHTT | |
| SCHEMBL29830272 | 0.69 | FGFR1 (0.62) | FGFR1ALDH1A1HPGDMAPTHTT | |
| SCHEMBL15826054 | 0.69 | PDE10A (0.44) | ALDH1A1HPGDMAPTPDE10ANOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1057088-C | Benzimidazole compounds, their use and preparation | NEUROSEARCH AS (DK) | 2000-10-04 | — | — | CN | disclosed |
| EP-0616807-B1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH AS (DK) | 1998-07-08 | — | — | EP | disclosed |
| US-5554632-A | CENTRAL NERVOUS SYSTEM | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| US-5554630-A | TREATING ANXIETY, CONVULSIONS AND SLEEP DISORDERS IN LIVING ANIMALS BY MODULATION OF THE BENZODIAZEPINE RECEPTOR OF THE CENTRAL NERVOUS SYSTEM WITH 1-/3-HETEROCYCLYLPHENYL/-BENZIMIDAZOLES | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| CN-1099391-A | Benzimidazole compounds, their use and preparation | NEUROSEARCH AS (JP) | 1995-03-01 | — | — | CN | disclosed |
| EP-0616807-A1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH A/S (DK) | 1994-09-28 | — | — | EP | disclosed |