Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646728 | 0.75 | FGFR1 (0.69) | KDM4EFGFR1ALDH1A1HPGDMEN1 | |
| SCHEMBL2646166 | 0.74 | FGFR1 (0.50) | FGFR1ALDH1A1HPGDMAPTHTT | |
| SCHEMBL2646173 | 0.74 | FGFR1 (0.50) | KDM4EFGFR1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL3205682 | 0.70 | SMN1; SMN2 (0.69) | NPSR1SMN1; SMN2ALDH1A1HPGDMEN1 | |
| SCHEMBL7472806 | 0.70 | PDE10A (0.45) | KDM4ENPSR1FGFR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2951988 | 0.69 | PDE10A (0.47) | KDM4ENPSR1FGFR1SMN1; SMN2ALDH1A1 | |
| Potassium Ion SCHEMBL6012184 | 0.68 | L3MBTL1 (0.51) | KDM4ESMN1; SMN2ALDH1A1HPGDMEN1 | |
| SCHEMBL2860553 | 0.68 | MET (0.40) | KDM4ENPSR1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL7984035 | 0.68 | L3MBTL1 (0.78) | KDM4ENPSR1SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL3044360 | 0.67 | L3MBTL1 (0.55) | KDM4ENPSR1SMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0616807-B1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH AS (DK) | 1998-07-08 | — | — | EP | disclosed |
| US-5554632-A | CENTRAL NERVOUS SYSTEM | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| US-5554630-A | TREATING ANXIETY, CONVULSIONS AND SLEEP DISORDERS IN LIVING ANIMALS BY MODULATION OF THE BENZODIAZEPINE RECEPTOR OF THE CENTRAL NERVOUS SYSTEM WITH 1-/3-HETEROCYCLYLPHENYL/-BENZIMIDAZOLES | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| EP-0616807-A1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH A/S (DK) | 1994-09-28 | — | — | EP | disclosed |