Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | GCK | P35557 | 10/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2647331 | 0.89 | KCNH2 (0.48) | KCNH2GCK | |
| SCHEMBL2647285 | 0.86 | KCNH2 (0.48) | KCNH2GCK | |
| SCHEMBL2650827 | 0.86 | KCNH2 (0.62) | KCNH2GCK | |
| SCHEMBL2647926 | 0.86 | KCNH2 (0.62) | KCNH2GCK | |
| SCHEMBL2649720 | 0.83 | KCNH2 (0.45) | KCNH2GCKEPHX1 | |
| SCHEMBL2645438 | 0.82 | KCNH2 (0.49) | KCNH2GCK | |
| SCHEMBL2662614 | 0.82 | KCNH2 (0.49) | KCNH2GCK | |
| SCHEMBL2646911 | 0.82 | KCNH2 (0.44) | KCNH2GCK | |
| SCHEMBL2667236 | 0.80 | GCK (0.57) | KCNH2GCKEPHX1 | |
| SCHEMBL2661615 | 0.79 | KCNH2 (0.43) | KCNH2GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169312-B1 | GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2004-10-06 | — | — | EP | disclosed |
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| US-6528543-B1 | Glucokinase activating for treating type II diabetes; acylurea compound, phenylacetyl-substituted; 1-(2-(3-chloro-phenyl)-3cyclopentyl-propionyl)-3-methyl-urea | HOFFMAN-LA ROCHE INC. | 2003-03-04 | — | — | US | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |
| EP-1169312-A2 | GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000058293-A2 | GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-10-05 | — | — | WO | disclosed |