Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | CTSC | P53634 | 5/20 | 0.39 |
| ▸ | GCK | P35557 | 6/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1861316 | 0.90 | KCNH2 (0.46) | KCNH2CTSCGCKCTSKPIK3CD | |
| SCHEMBL1861318 | 0.90 | KCNH2 (0.46) | KCNH2CTSCGCKCTSKPIK3CD | |
| SCHEMBL2646113 | 0.87 | KCNH2 (0.46) | KCNH2CTSCGCKCTSKPIK3CD | |
| SCHEMBL2649013 | 0.83 | KCNH2 (0.47) | KCNH2CTSCGCKCTSKCTSB | |
| SCHEMBL2662616 | 0.83 | KCNH2 (0.47) | KCNH2CTSCGCKCTSKCTSB | |
| SCHEMBL2650827 | 0.83 | KCNH2 (0.62) | KCNH2GCK | |
| SCHEMBL2646451 | 0.83 | KCNH2 (0.47) | KCNH2GCKEPHX1 | |
| SCHEMBL2647926 | 0.83 | KCNH2 (0.62) | KCNH2GCK | |
| SCHEMBL2646911 | 0.79 | KCNH2 (0.44) | KCNH2GCK | |
| SCHEMBL2658950 | 0.79 | KCNH2 (0.60) | KCNH2GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169312-B1 | GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2004-10-06 | — | — | EP | disclosed |
| US-6528543-B1 | Glucokinase activating for treating type II diabetes; acylurea compound, phenylacetyl-substituted; 1-(2-(3-chloro-phenyl)-3cyclopentyl-propionyl)-3-methyl-urea | HOFFMAN-LA ROCHE INC. | 2003-03-04 | — | — | US | disclosed |
| EP-1169312-A2 | GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000058293-A2 | GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-10-05 | — | — | WO | disclosed |