Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8578555 | 0.91 | PADI4 (0.57) | PADI4CYP19A1CYP11B1CYP11B2NPC1 | |
| SCHEMBL26467467 | 0.85 | CYP2A6 (0.47) | PADI4CYP19A1CYP2A6CYP1A2CYP2D6 | |
| SCHEMBL26467485 | 0.84 | ATP6V1B1 (0.49) | PADI4CYP19A1CYP2A6CYP1A2CYP2D6 | |
| SCHEMBL26467449 | 0.83 | CYP2A6 (0.55) | NPC1RAB9AMEN1KMT2ACYP2A6 | |
| SCHEMBL15359580 | 0.81 | CYP2A6 (0.64) | NPC1RAB9ACYP2A6CYP1A2CYP2D6 | |
| SCHEMBL26467457 | 0.80 | ATP6V1B1 (0.49) | PADI4CYP19A1RAB9AKMT2ACYP2A6 | |
| SCHEMBL26467443 | 0.76 | CYP2A6 (0.50) | NPC1RAB9AMEN1KMT2ACYP2A6 | |
| SCHEMBL26468218 | 0.76 | NPC1 (0.37) | PADI4CYP11B1CYP11B2NPC1RAB9A | |
| SCHEMBL2458425 | 0.74 | CYP2A6 (0.69) | NPC1RAB9ACYP2A6CYP1A2CYP2D6 | |
| SCHEMBL2458423 | 0.74 | CYP2A6 (0.69) | NPC1RAB9ACYP2A6CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133538-A1 | TARGETED DEGRADERS OF ABERRANT TAU BASED ON THE PET TRACER PBB3 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133538-A1 | TARGETED DEGRADERS OF ABERRANT TAU BASED ON THE PET TRACER PBB3 | MAPT, PSEN1, PSEN2 | PADI4 4391/4885CYP19A1 3844/4885CYP11B1 4165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.