Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.35 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872769 | 0.74 | GAA (0.50) | GAAMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL29581536 | 0.74 | MAPT (0.55) | GAAMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL2647288 | 0.72 | MEN1 (0.38) | GAAMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL12600384 | 0.72 | MEN1 (0.55) | GAAMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL12601176 | 0.69 | PIK3CA (0.51) | MEN1KMT2AL3MBTL1EGFRNPC1 | |
| SCHEMBL13010773 | 0.69 | TSHR (0.39) | ALDH1A1KDM4EL3MBTL1NPC1 | |
| SCHEMBL824204 | 0.68 | ALDH1A1 (0.53) | GAAMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL21416946 | 0.68 | ALDH1A1 (0.53) | GAAMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL12415761 | 0.68 | GAA (0.46) | GAAMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL24126841 | 0.67 | AKR1C3 (0.47) | MAPTMEN1ALDH1A1KMT2AGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0616807-B1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH AS (DK) | 1998-07-08 | — | — | EP | disclosed |
| US-5554632-A | CENTRAL NERVOUS SYSTEM | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| US-5554630-A | TREATING ANXIETY, CONVULSIONS AND SLEEP DISORDERS IN LIVING ANIMALS BY MODULATION OF THE BENZODIAZEPINE RECEPTOR OF THE CENTRAL NERVOUS SYSTEM WITH 1-/3-HETEROCYCLYLPHENYL/-BENZIMIDAZOLES | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| EP-0616807-A1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH A/S (DK) | 1994-09-28 | — | — | EP | disclosed |