Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 17/20 | 0.47 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.46 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.46 |
| ▸ | GIPR | P48546 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.43 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.43 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.43 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.43 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.43 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.43 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.43 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.43 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.43 |
| ▸ | GLP1R | P43220 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2647087 | 1.00 | GCGR (0.47) | GCGRKCNK2KCNK10GIPRCYP3A4 | |
| SCHEMBL2647920 | 0.92 | GCGR (0.53) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2647916 | 0.92 | GCGR (0.53) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2665074 | 0.90 | GCGR (0.46) | GCGRKCNK2KCNK10GIPRCYP3A4 | |
| SCHEMBL2647844 | 0.89 | TRPV1 (0.51) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2647843 | 0.89 | TRPV1 (0.51) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2655666 | 0.87 | GCGR (0.49) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2648073 | 0.87 | GCGR (0.49) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2648068 | 0.87 | GCGR (0.49) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2655670 | 0.87 | GCGR (0.49) | GCGRGIPRCYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463715-A1 | NOVEL GLUCAGON ANTAGONISTS | NOVO NORDISK A/S (DK) | 2004-10-06 | — | — | EP | disclosed |
| US-6762318-B2 | CARBOXYLIC ACID OR TETRAZOLE DERIVATIZED SECONDARY AMIDES; ORAL ADMINISTRATION | NOVO NORDISK A/S (DK) | 2004-07-13 | — | — | US | disclosed |
| WO-2003048109-A1 | NOVEL GLUCAGON ANTAGONISTS | NOVO NORDISK A/S (DK) | 2003-06-12 | — | — | WO | disclosed |