Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 15/20 | 0.46 |
| ▸ | GIPR | P48546 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.43 |
| ▸ | GLP1R | P43220 | 1/20 | 0.42 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.41 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.41 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.41 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.41 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.41 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.41 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.41 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.41 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.41 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.40 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2647087 | 0.90 | GCGR (0.47) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2647091 | 0.90 | GCGR (0.47) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL6917434 | 0.89 | GCGR (0.50) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2664934 | 0.89 | GCGR (0.50) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2647844 | 0.87 | TRPV1 (0.51) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2647843 | 0.87 | TRPV1 (0.51) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2665047 | 0.86 | GCGR (0.45) | GCGRGIPRTRPV1KCNK2KCNK10 | |
| SCHEMBL2647920 | 0.86 | GCGR (0.53) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2647916 | 0.86 | GCGR (0.53) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2665083 | 0.83 | GCGR (0.44) | GCGRGIPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003048109-A1 | NOVEL GLUCAGON ANTAGONISTS | NOVO NORDISK A/S (DK) | 2003-06-12 | — | — | WO | disclosed |