Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 16/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CBFB | Q13951 | 2/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2645647 | 0.90 | GCK (0.51) | GCKKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2644746 | 0.89 | GCK (0.49) | GCKKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2645213 | 0.89 | GCK (0.51) | GCKNPC1RAB9ACBFB | |
| SCHEMBL2646017 | 0.89 | CHEK2 (0.48) | GCKKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2650150 | 0.86 | NPC1 (0.46) | GCKKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2645464 | 0.85 | NPC1 (0.60) | GCKKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2645994 | 0.85 | GCK (0.58) | GCKCBFB | |
| SCHEMBL2647747 | 0.84 | GCK (0.51) | GCK | |
| SCHEMBL2645280 | 0.82 | GCK (0.52) | GCKNPC1RAB9ACBFB | |
| SCHEMBL2646729 | 0.81 | CBFB (0.47) | GCKKDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1702919-B1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | MSD KK (JP) | 2012-05-30 | — | — | EP | disclosed |
| EP-1702919-A1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-09-20 | — | — | EP | disclosed |