Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 16/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.48 |
| ▸ | CBFB | Q13951 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2645213 | 0.90 | GCK (0.51) | GCKCHEK2NPC1RAB9ARUNX1 | |
| SCHEMBL2646514 | 0.89 | CHEK2 (0.60) | GCKCHEK2NPC1RAB9A | |
| SCHEMBL2645717 | 0.89 | GCK (0.53) | GCKCHEK2NPC1RAB9ARUNX1 | |
| SCHEMBL2645464 | 0.87 | NPC1 (0.60) | GCKNPC1RAB9ARUNX1CBFB | |
| SCHEMBL2645586 | 0.84 | GCK (0.59) | GCKNPC1RAB9ARUNX1CBFB | |
| SCHEMBL2646351 | 0.84 | CHEK2 (0.55) | GCKCHEK2NPC1RAB9ACBFB | |
| SCHEMBL2645647 | 0.83 | GCK (0.51) | GCKNPC1RAB9ACBFB | |
| SCHEMBL2647102 | 0.82 | GCK (0.47) | GCKNPC1RAB9ACBFB | |
| SCHEMBL2644746 | 0.82 | GCK (0.49) | GCKNPC1RAB9ACBFB | |
| SCHEMBL2645613 | 0.81 | METAP2 (0.57) | GCKCHEK2NPC1RAB9ARUNX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1702919-B1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | MSD KK (JP) | 2012-05-30 | — | — | EP | disclosed |
| EP-1702919-A1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-09-20 | — | — | EP | disclosed |