Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 8/20 | 0.78 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.63 |
| ▸ | RAF1 | P04049 | 6/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.59 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2647350 | 0.88 | GCGR (1.00) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2647720 | 0.84 | MAPK13 (0.78) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6469564 | 0.84 | MAPK13 (0.78) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6465619 | 0.83 | MAPK13 (0.90) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2647655 | 0.83 | MAPK14 (0.89) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2650776 | 0.82 | MAPK13 (0.74) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2648558 | 0.81 | MAPK14 (0.74) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2647500 | 0.80 | GCGR (0.76) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2648525 | 0.79 | MAPK13 (0.73) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2650500 | 0.78 | MAPK14 (0.79) | GCGRMAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0959886-A4 | TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS | MERCK & CO INC (US) | 2001-05-02 | — | — | EP | claimed |
| EP-0959886-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS | Merck & Co., Inc. (US) | 1999-12-01 | — | — | EP | claimed |
| WO-1998022109-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | claimed |
| EP-0959886-A4 | TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS | MERCK & CO INC (US) | 2001-05-02 | — | — | EP | disclosed |
| EP-0959886-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS | Merck & Co., Inc. (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5880139-A | TREATING DIABETES, OBESITY, HYPERTENSION, CACHEXIA | MERCK & CO., INC. (US) | 1999-03-09 | — | — | US | disclosed |
| WO-1998022109-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | disclosed |