SCHEMBL2647307

SCHEMBL2647307

Cc1ccccc1CBr.c1ccc(P(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
TAAR1 Q96RJ0 1/20 0.41
ESR1 P03372 2/20 0.39
ESR2 Q92731 2/20 0.39
ALDH1A1 P00352 3/20 0.36
HPGD P15428 1/20 0.36
CTBP2 P56545 1/20 0.36
CHRM2 P08172 1/20 0.35
PTGS1 P23219 1/20 0.35
PTGS2 P35354 1/20 0.35
MAPT P10636 1/20 0.35
TSHR P16473 2/20 0.35
ACHE P22303 1/20 0.35
TRPA1 O75762 1/20 0.34
KMT2A Q03164 2/20 0.34
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1043879 0.87 CYP3A4 (0.43) CYP3A4TDP1TAAR1ESR1ESR2
SCHEMBL29502975 0.85
SCHEMBL4784 0.85
SCHEMBL11027874 0.83 TAAR1 (0.50) TAAR1ALDH1A1HPGDCTBP2CHRM2
SCHEMBL7268528 0.83 TAAR1 (0.50) TAAR1ALDH1A1HPGDCTBP2CHRM2
O-Xylene SCHEMBL5617302 0.78 CYP3A4 (0.71) CYP3A4TDP1ESR1ESR2ALDH1A1
SCHEMBL2555255 0.78 CYP3A4 (0.50) CYP3A4TDP1TAAR1ESR1ESR2
SCHEMBL21931634 0.76 ESR1 (0.48) CYP3A4TDP1TAAR1ESR1ESR2
SCHEMBL7364761 0.76 CYP3A4 (0.48) CYP3A4TDP1TAAR1ESR1ESR2
Bromoethane SCHEMBL43961 0.75 TDP1 (0.67) CYP3A4TDP1ESR1ESR2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3883925-A1 CYCLIC UREAS Sironax Ltd (KY) 2021-09-29 EP disclosed
CN-113302183-A Cyclic ureas 圣瑞诺有限公司 2021-08-24 CN disclosed
EP-0934065-B1 NOVEL CRYPTOPHYCIN DERIVATIVES AS ANTI-NEOPLASTIC AGENTS UNIV HAWAII (US) 2006-06-07 EP disclosed
US-6680311-B1 ANTICARCINOGENIC, ANTITUMOR AND ANTIPROLIFERATIVE AGENTS ELI LILLY AND COMPANY 2004-01-20 US disclosed
US-6218431-B1 GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES BAYER CORPORATION 2001-04-17 US disclosed
EP-0934065-A4 PHARMACEUTICAL COMPOUNDS LILLY CO ELI (US) 2000-10-11 EP disclosed
EP-0934065-A1 PHARMACEUTICAL COMPOUNDS ELI LILLY AND COMPANY (US) 1999-08-11 EP disclosed
EP-0934274-A1 SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS Bayer Corporation (US) 1999-08-11 EP disclosed
WO-1998008505-A1 PHARMACEUTICAL COMPOUNDS ELI LILLY AND COMPANY (US) 1998-03-05 WO disclosed
WO-1998004528-A2 SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS BAYER CORPORATION (US) 1998-02-05 WO disclosed