SCHEMBL2647425

SCHEMBL2647425

COc1cc(NC(=O)Cc2csc3ccccc23)ccc1C=NNC(=O)c1ccc(O)c(Cl)c1

nearest known ligand 0.73

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
GCGR P47871 20/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2646991 0.89 GCGR (0.69) GCGR
SCHEMBL2662617 0.85 GCGR (0.59) GCGR
SCHEMBL7236629 0.85 GCGR (1.00) GCGR
SCHEMBL2646472 0.84 GCGR (0.68) GCGR
SCHEMBL2646473 0.84 GCGR (0.68) GCGR
SCHEMBL2645711 0.82 GCGR (0.68) GCGR
SCHEMBL2645708 0.82 GCGR (0.68) GCGR
SCHEMBL2646990 0.82 GCGR (0.80) GCGR
SCHEMBL2646988 0.82 GCGR (0.80) GCGR
SCHEMBL2647421 0.80 GCGR (0.57) GCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6613942-B1 Nonpeptide; 4-hydroxy benzoic acid hydrazides NOVO NORDISK A/S (DK) 2003-09-02 US claimed
EP-1140823-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 2001-10-10 EP claimed
WO-2000039088-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 2000-07-06 WO claimed
US-6613942-B1 Nonpeptide; 4-hydroxy benzoic acid hydrazides NOVO NORDISK A/S (DK) 2003-09-02 US disclosed
EP-1140823-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 2001-10-10 EP disclosed
WO-2000039088-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 2000-07-06 WO disclosed