SCHEMBL26481237

SCHEMBL26481237

CC1CC(c2cccc(-c3c[nH]c4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 20/20 0.64
▸ CBL P22681 15/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26481225 0.88 CBLB (0.66) CBLBCBL
SCHEMBL26481226 0.87 CBLB (0.64) CBLBCBL
SCHEMBL26481222 0.87 CBLB (0.64) CBLBCBL
SCHEMBL30152679 0.83 CBLB (0.61) CBLBCBL
SCHEMBL24819991 0.83 CBLB (0.61) CBLBCBL
SCHEMBL26106133 0.81 CBLB (0.78) CBLBCBL
SCHEMBL26108150 0.81 CBLB (0.78) CBLBCBL
SCHEMBL26481221 0.81 CBLB (0.67) CBLBCBL
SCHEMBL30311255 0.81 CBLB (0.78) CBLBCBL
SCHEMBL26482318 0.81 CBLB (0.78) CBLBCBL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023072273-A1 POLYCYCLIC COMPOUND AS CBL-B INHIBITOR 先声再明医药有限公司 2023-05-04 — — WO disclosed
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