Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GCGR | P47871 | 1/20 | 0.47 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2648931 | 0.91 | GCGR (0.61) | MAPTMEN1KMT2AKDM4EHSP90AA1 | |
| SCHEMBL2648108 | 0.90 | MAPT (0.45) | MAPTMEN1KMT2AKDM4EHSP90AA1 | |
| SCHEMBL2648212 | 0.86 | GCGR (0.62) | MAPTMEN1KMT2AKDM4EHTT | |
| SCHEMBL2648083 | 0.85 | MAPT (0.41) | MAPTMEN1KMT2AKDM4EHSP90AA1 | |
| SCHEMBL8949567 | 0.83 | MAPT (0.69) | MAPTMEN1KMT2AKDM4EHTT | |
| SCHEMBL3739958 | 0.77 | MAPT (0.73) | MAPTMEN1KMT2AKDM4EHSP90AA1 | |
| SCHEMBL2648227 | 0.77 | GCGR (0.60) | ALDH1A1GCGRSLC10A2L3MBTL1 | |
| SCHEMBL4464787 | 0.77 | MAPT (0.51) | MAPTMEN1KMT2AKDM4EHSP90AA1 | |
| SCHEMBL2647286 | 0.77 | GCGR (0.79) | GCGR | |
| SCHEMBL2649452 | 0.77 | HTT (0.46) | MAPTMEN1KMT2AKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | disclosed |