Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 12/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26485299 | 0.87 | MAT2A (0.40) | MAT2APRMT5CYP3A4PIK3CDPIK3R1 | |
| SCHEMBL30419481 | 0.87 | MAT2A (0.40) | MAT2APRMT5CYP3A4PIK3CDPIK3R1 | |
| SCHEMBL30420264 | 0.85 | MAT2A (0.52) | MAT2APRMT5CYP3A4LMNAGFER | |
| SCHEMBL26485127 | 0.85 | MAT2A (0.52) | MAT2APRMT5CYP3A4LMNAGFER | |
| SCHEMBL29571509 | 0.85 | MAT2A (0.66) | MAT2APRMT5CYP3A4LMNAGFER | |
| SCHEMBL22103156 | 0.85 | MAT2A (0.66) | MAT2APRMT5CYP3A4LMNAGFER | |
| SCHEMBL26485225 | 0.83 | MAT2A (0.40) | MAT2APIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL26485805 | 0.82 | MAT2A (0.48) | MAT2APRMT5CYP3A4LMNAGFER | |
| SCHEMBL26485928 | 0.79 | MAT2A (0.51) | MAT2APRMT5CYP3A4LMNAGFER | |
| SCHEMBL30420000 | 0.79 | MAT2A (0.51) | MAT2APRMT5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023066283-A1 | METHIONINE ADENOSYLTRANSFERASE 2A (MAT2A) INHIBITORS AND USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2023-04-27 | — | — | WO | disclosed |