Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.75 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.75 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.75 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.75 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.75 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.75 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 13/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667911 | 0.89 | GABRA1 (0.81) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3767321 | 0.89 | GABRA1 (0.81) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2648872 | 0.87 | GABRA1 (0.78) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2643507 | 0.87 | GABRA1 (0.69) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2648537 | 0.86 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL17236316 | 0.86 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2650372 | 0.85 | GABRA1 (0.83) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2649184 | 0.85 | GABRA1 (0.83) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1762041 | 0.83 | GABRA1 (0.55) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1762043 | 0.83 | GABRA1 (0.55) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922725-A | Benzimidazole compounds and their use as modulators of the GABAA receptor complex | NEUROSEARCH A/S (DK) | 1999-07-13 | — | — | US | claimed |
| EP-0821682-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1998-02-04 | — | — | EP | claimed |
| WO-1996033191-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1996-10-24 | — | — | WO | claimed |
| US-5922725-A | Benzimidazole compounds and their use as modulators of the GABAA receptor complex | NEUROSEARCH A/S (DK) | 1999-07-13 | — | — | US | disclosed |
| EP-0821682-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033191-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1996-10-24 | — | — | WO | disclosed |