Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.44 |
| ▸ | SIK1 | P57059 | 2/20 | 0.43 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.43 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649581 | 0.83 | GABRA1 (0.43) | FGFR1KDRSRCALDH1A1HPGD | |
| SCHEMBL2648797 | 0.82 | HPGD (0.47) | FGFR1KDRALDH1A1HPGD | |
| SCHEMBL2658127 | 0.81 | FGFR1 (0.40) | FGFR1KDRSRCALDH1A1 | |
| SCHEMBL1761712 | 0.81 | GABRA1 (0.44) | FGFR1KDRSRCALDH1A1HPGD | |
| SCHEMBL2649006 | 0.80 | FGFR1 (0.67) | FGFR1SIK1SIK2SIK3MEN1 | |
| SCHEMBL1761821 | 0.80 | FGFR1 (0.45) | FGFR1KDRSRC | |
| SCHEMBL2650162 | 0.80 | FGFR1 (0.43) | FGFR1KDRSRCALDH1A1HPGD | |
| SCHEMBL2648539 | 0.80 | KDR (0.41) | FGFR1KDRSRCALDH1A1HPGD | |
| SCHEMBL12415699 | 0.79 | FGFR1 (0.54) | FGFR1SIK1SIK2SIK3MEN1 | |
| SCHEMBL2648738 | 0.79 | GABRA1 (0.41) | FGFR1KDRSRCALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821682-B1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA-A RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2000-07-19 | — | — | EP | disclosed |
| US-5922725-A | Benzimidazole compounds and their use as modulators of the GABAA receptor complex | NEUROSEARCH A/S (DK) | 1999-07-13 | — | — | US | disclosed |
| EP-0821682-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033191-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1996-10-24 | — | — | WO | disclosed |