Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23978561 | 0.88 | CYP1A2 (0.46) | CYP1A2RPS6KB1NCF1HTR3AHRH4 | |
| SCHEMBL23773568 | 0.81 | CYP1A2 (0.41) | CYP1A2RPS6KB1NCF1HTR3AHRH4 | |
| SCHEMBL12003727 | 0.80 | CYP1A2 (0.56) | CYP1A2NCF1HTR3AHRH4KDM4E | |
| SCHEMBL31391395 | 0.80 | CYP1A2 (0.56) | CYP1A2NCF1HTR3AHRH4KDM4E | |
| SCHEMBL17061539 | 0.75 | CYP1A2 (0.47) | CYP1A2NCF1HTR3AHRH4KDM4E | |
| SCHEMBL3337226 | 0.75 | CYP1A2 (0.47) | CYP1A2NCF1HTR3AHRH4KDM4E | |
| SCHEMBL23978672 | 0.72 | CYP1A2 (0.45) | CYP1A2RPS6KB1NCF1HTR3AHRH4 | |
| Hydrochloric Acid SCHEMBL10583130 | 0.71 | CYP1A2 (0.47) | CYP1A2NCF1KDM4EEGFR | |
| SCHEMBL4547884 | 0.67 | CYP1A2 (0.43) | CYP1A2NCF1HTR3AHRH4PCSK9 | |
| SCHEMBL31326061 | 0.67 | CYP1A2 (0.43) | CYP1A2NCF1HTR3AHRH4PCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11643388-B2 | Inhibitors of alpha 2 beta 1 integrin and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11643388-B2 | Inhibitors of alpha 2 beta 1 integrin and methods of use thereof | ITGB1, ITGB2, ITGA2 | CYP1A2 2939/4885RPS6KB1 836/4885NCF1 617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.