Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.46 |
| ▸ | NMT1 | P30419 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2647297 | 0.87 | LMNA (0.44) | LMNAL3MBTL1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL2649451 | 0.87 | LMNA (0.44) | LMNAL3MBTL1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL8949567 | 0.86 | MAPT (0.69) | LMNAL3MBTL1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL2648334 | 0.82 | PTGER1 (0.45) | LMNAL3MBTL1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL9269271 | 0.82 | GCGR (0.57) | LMNASMN1; SMN2GAAALDH1A1MAPT | |
| SCHEMBL9265076 | 0.79 | GCGR (0.56) | LMNASMN1; SMN2GAAALDH1A1MAPT | |
| SCHEMBL2648212 | 0.78 | GCGR (0.62) | LMNAL3MBTL1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL2648000 | 0.77 | MEN1 (0.43) | LMNAL3MBTL1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL2647997 | 0.77 | MEN1 (0.43) | LMNAL3MBTL1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL2650419 | 0.77 | PPIA (0.41) | LMNAL3MBTL1SMN1; SMN2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | disclosed |