Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GCK | P35557 | 2/20 | 0.35 |
| ▸ | IDH2 | P48735 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | PLK1 | P53350 | 2/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | OGA | O60502 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1341072 | 0.93 | IDH2 (0.37) | SMN1; SMN2GCKIDH2MAPK14MAPK13 | |
| SCHEMBL2649787 | 0.93 | KMT2A (0.37) | SMN1; SMN2GCKIDH2MAPK14MAPK13 | |
| SCHEMBL1342290 | 0.93 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPK14PLK1MAPK13KMT2A | |
| SCHEMBL1341909 | 0.85 | RORC (0.40) | SMN1; SMN2GCKIDH2MAPK14MAPK13 | |
| SCHEMBL1342294 | 0.85 | ACKR3 (0.35) | SMN1; SMN2GCKIDH2MAPK14MAPK13 | |
| SCHEMBL1342043 | 0.84 | MAPK14 (0.39) | SMN1; SMN2MAPK14MAPK13OGANPC1 | |
| SCHEMBL1342945 | 0.84 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPK14MAPK13KMT2AALDH1A1 | |
| SCHEMBL1343022 | 0.84 | TP53 (0.37) | SMN1; SMN2MAPK14MAPK13ALDH1A1ACKR3 | |
| SCHEMBL1342705 | 0.83 | MAPK14 (0.39) | SMN1; SMN2MAPK14MAPK13KMT2AALDH1A1 | |
| SCHEMBL1343092 | 0.83 | MAPK14 (0.38) | SMN1; SMN2IDH2MAPK14MAPK13KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |