Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.76 |
| ▸ | MAPK13 | O15264 | 16/20 | 0.76 |
| ▸ | MAPK12 | P53778 | 16/20 | 0.76 |
| ▸ | MAPK11 | Q15759 | 16/20 | 0.76 |
| ▸ | GCGR | P47871 | 11/20 | 0.76 |
| ▸ | RAF1 | P04049 | 8/20 | 0.72 |
| ▸ | BRAF | P15056 | 2/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6469901 | 0.95 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL2650673 | 0.85 | MAPK13 (0.86) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL6470896 | 0.85 | MAPK13 (0.86) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL6470581 | 0.84 | MAPK13 (0.81) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5921859 | 0.84 | MAPK13 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL6469111 | 0.84 | MAPK13 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL2649730 | 0.84 | MAPK13 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL6471005 | 0.84 | MAPK13 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL6469564 | 0.83 | MAPK13 (0.78) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL2647720 | 0.83 | MAPK13 (0.78) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0959885-A4 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO INC (US) | 2002-07-17 | — | — | EP | claimed |
| EP-0959885-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | Merck & Co., Inc. (US) | 1999-12-01 | — | — | EP | claimed |
| WO-1998022108-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | claimed |
| EP-0959885-A4 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO INC (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-0959885-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | Merck & Co., Inc. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998022108-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | disclosed |
| WO-1998022108-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | disclosed |