Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | IDH2 | P48735 | 1/20 | 0.31 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343047 | 0.94 | MAPK14 (0.38) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1343750 | 0.94 | SMN1; SMN2 (0.37) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1343232 | 0.85 | CNR1 (0.42) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2649986 | 0.84 | MAPK14 (0.37) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1340887 | 0.84 | SMN1; SMN2 (0.41) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6696998 | 0.83 | MAPK14 (0.40) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1344039 | 0.82 | SMN1; SMN2 (0.38) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1341694 | 0.81 | SMN1; SMN2 (0.40) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1342322 | 0.81 | MAPK14 (0.40) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1343709 | 0.81 | LCK (0.42) | MAPK14MAPK13SMN1; SMN2MAPTABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |