Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343047 | 0.85 | MAPK14 (0.38) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2649982 | 0.84 | MAPK14 (0.35) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1343750 | 0.84 | SMN1; SMN2 (0.37) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1340887 | 0.82 | SMN1; SMN2 (0.41) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1343232 | 0.80 | CNR1 (0.42) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1341694 | 0.79 | SMN1; SMN2 (0.40) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1344039 | 0.79 | SMN1; SMN2 (0.38) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4470766 | 0.78 | SMN1; SMN2 (0.40) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1339818 | 0.78 | SMN1; SMN2 (0.40) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1340876 | 0.78 | MAPK14 (0.38) | MAPK14MAPK13SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |