Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 17/20 | 1.00 |
| ▸ | MAPK12 | P53778 | 17/20 | 1.00 |
| ▸ | MAPK11 | Q15759 | 17/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 17/20 | 1.00 |
| ▸ | GCGR | P47871 | 8/20 | 1.00 |
| ▸ | RAF1 | P04049 | 8/20 | 0.83 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.82 |
| ▸ | BRAF | P15056 | 2/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6469543 | 1.00 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL11176392 | 0.92 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL7228717 | 0.91 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL2949385 | 0.91 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL2650673 | 0.87 | MAPK13 (0.86) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL2648930 | 0.87 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL6470896 | 0.87 | MAPK13 (0.86) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL6469294 | 0.87 | MAPK13 (0.76) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL6470581 | 0.86 | MAPK13 (0.81) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL28158811 | 0.86 | MAPK13 (0.86) | MAPK13MAPK12MAPK11MAPK14GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0959885-A4 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO INC (US) | 2002-07-17 | — | — | EP | claimed |
| EP-0959885-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | Merck & Co., Inc. (US) | 1999-12-01 | — | — | EP | claimed |
| WO-1998022108-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | claimed |
| EP-0959885-A4 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO INC (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-0959885-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | Merck & Co., Inc. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998022108-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | disclosed |