Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.46 |
| ▸ | PI4KA | P42356 | 1/20 | 0.46 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.46 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28311213 | 0.98 | PDE5A (0.54) | PDE5AMAP4K4HTR1AADRA1DADRA1A | |
| SCHEMBL3240985 | 0.79 | HTR1A (0.50) | PDE5AHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL11583026 | 0.79 | HTR1A (0.50) | HTR1AADRA1DADRA1AADRA1BEGFR | |
| SCHEMBL857736 | 0.78 | MEN1 (0.55) | HTR1AADRA1DADRA1AADRA1BEGFR | |
| SCHEMBL20813844 | 0.78 | HTR1A (0.49) | PDE5AHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL29461230 | 0.78 | MEN1 (0.55) | HTR1AADRA1DADRA1AADRA1BEGFR | |
| SCHEMBL3507559 | 0.78 | HTR1A (0.49) | HTR1AADRA1DADRA1AADRA1BEGFR | |
| SCHEMBL29828879 | 0.77 | PI4KA (0.42) | PDE5AMAP4K4LIMK1PI4KAPI4K2B | |
| SCHEMBL17142275 | 0.77 | PDE5A (0.51) | PDE5AMAP4K4LIMK1KDM4E | |
| SCHEMBL10968627 | 0.77 | PI4KA (0.48) | MAP4K4HTR1AADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118239931-A | As P2X3Aminoquinazoline derivatives of inhibitors | 奇斯药制品公司 | 2024-06-25 | — | — | CN | claimed |
| CN-114269432-B | As P2X3Aminoquinazoline derivatives of inhibitors | 奇斯药制品公司 | 2024-05-07 | — | — | CN | claimed |
| CN-114269432-A | As P2X3Aminoquinazoline derivatives as inhibitors | 奇斯药制品公司 | 2022-04-01 | — | — | CN | claimed |
| CN-113039182-B | Inhibitors of YAP/TAZ-TEAD interactions and their use in cancer treatment | 伊文蒂瓦公司 | 2024-02-20 | — | — | CN | disclosed |
| CN-115536696-B | ENPP1 inhibitors | 上海齐鲁制药研究中心有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-115536696-A | ENPP1 inhibitors | 上海齐鲁制药研究中心有限公司 | 2022-12-30 | — | — | CN | disclosed |