Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT2B7 | P16662 | 1/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7699358 | 0.80 | UGT2B7 (0.52) | UGT2B7AOC3CYP1A2CYP2A6CYP3A4 | |
| SCHEMBL4411103 | 0.79 | UGT2B7 (0.55) | UGT2B7AOC3CYP1A2CYP2A6CYP3A4 | |
| SCHEMBL1753651 | 0.78 | UGT2B7 (0.59) | UGT2B7AOC3CYP1A2CYP2A6CYP3A4 | |
| SCHEMBL132329 | 0.77 | UGT2B7 (0.63) | UGT2B7AOC3CYP1A2CYP2A6CYP2D6 | |
| SCHEMBL9670288 | 0.76 | UGT2B7 (0.56) | UGT2B7AOC3CYP1A2CYP2A6CYP3A4 | |
| SCHEMBL15345447 | 0.76 | AOC3 (0.54) | UGT2B7AOC3CYP1A2CYP2A6CYP3A4 | |
| SCHEMBL20976148 | 0.76 | UGT2B7 (0.62) | UGT2B7AOC3CYP1A2CYP2A6CYP3A4 | |
| SCHEMBL16174482 | 0.76 | AOC3 (0.54) | UGT2B7AOC3CYP1A2CYP2A6CYP3A4 | |
| SCHEMBL27956302 | 0.76 | AOC3 (0.62) | UGT2B7AOC3CYP1A2CYP2A6CYP3A4 | |
| SCHEMBL11255630 | 0.76 | AOC3 (0.62) | UGT2B7AOC3CYP1A2CYP2A6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404335-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | Astrazeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000267-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |