SCHEMBL2650786

O=C(O)CCNC(=O)c1ccc(C(NC(=O)Nc2ccc(OC(F)(F)F)c(-c3nc4ccccc4o3)c2)c2ccc(C3=CCCCC3)cc2)cc1.O=C(O)CCNC(=O)c1ccc(C(NC(=O)Nc2ccc(OC(F)(F)F)c(-c3nc4ccccc4o3)c2)c2ccc(C3CCCCC3)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	GCGR	P47871	19/20	0.42

▸	GIPR	P48546	9/20	0.40

▸	ADCY6	O43306	1/20	0.37

▸	ADCY3	O60266	1/20	0.37

▸	ADCY9	O60503	1/20	0.37

▸	ADCY5	O95622	1/20	0.37

▸	ADCY8	P40145	1/20	0.37

▸	ADCY7	P51828	1/20	0.37

▸	ADCY2	Q08462	1/20	0.37

▸	ADCY1	Q08828	1/20	0.37

▸	ADCY4	Q8NFM4	1/20	0.37

▸	GLP1R	P43220	1/20	0.36

▸	S1PR1	P21453	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6752072	0.94	GCGR (0.44)	GCGRGIPRADCY6ADCY3ADCY9
SCHEMBL6752432	0.93	GCGR (0.44)	GCGRGIPRADCY6ADCY3ADCY9
SCHEMBL2650782	0.88	GCGR (0.59)	GCGRGIPRGLP1R
SCHEMBL2650784	0.83	GCGR (0.52)	GCGRGIPRGLP1R
SCHEMBL2651297	0.82	GCGR (0.51)	GCGRGIPRADCY6ADCY3ADCY9
SCHEMBL6752428	0.81	GCGR (0.66)	GCGRGIPRADCY6ADCY3ADCY9
SCHEMBL2666060	0.81	GCGR (0.58)	GCGRGIPRGLP1R
SCHEMBL2651558	0.80	GCGR (0.44)	GCGRGIPR
SCHEMBL2649840	0.78	GCGR (0.42)	GCGRGIPRADCY6ADCY3ADCY9
SCHEMBL2650853	0.78	GCGR (0.46)	GCGRGIPRADCY6ADCY3ADCY9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2002040444-A1	GLUCAGON ANTAGONISTS/INVERSE AGONISTS	NOVO NORDISK A/S (DK)	2002-05-23	—	—	WO	claimed