Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 11/20 | 0.75 |
| ▸ | AXL | P30530 | 1/20 | 0.66 |
| ▸ | NEK2 | P51955 | 1/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.61 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.59 |
| ▸ | MET | P08581 | 1/20 | 0.59 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32690420 | 0.90 | PTK2 (0.76) | PTK2AXLNEK2ALKZAP70 | |
| SCHEMBL28881814 | 0.89 | ALK (0.75) | PTK2AXLNEK2ALKHDAC1 | |
| SCHEMBL14981318 | 0.85 | PTK2 (0.77) | PTK2AXLNEK2ALKZAP70 | |
| SCHEMBL28881275 | 0.85 | CCNK (0.77) | PTK2AXLNEK2ALKHDAC1 | |
| SCHEMBL11916626 | 0.85 | ALK (0.77) | PTK2ALKHDAC1METHDAC2 | |
| SCHEMBL21625803 | 0.84 | PTK2 (0.67) | PTK2AXLNEK2ALKHDAC1 | |
| SCHEMBL21625808 | 0.83 | PTK2 (0.65) | PTK2AXLNEK2ALKHDAC1 | |
| SCHEMBL18350626 | 0.82 | ALK (0.83) | ALKHDAC1ZAP70METINSR | |
| SCHEMBL24044993 | 0.82 | MAPK9 (0.77) | PTK2INSR | |
| SCHEMBL21625799 | 0.81 | PTK2 (0.66) | PTK2ALKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192578-A1 | PROTEIN DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |