Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 11/20 | 0.49 |
| ▸ | GIPR | P48546 | 8/20 | 0.49 |
| ▸ | GLP1R | P43220 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.40 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.40 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.40 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.40 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.40 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.40 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651789 | 0.92 | GCGR (0.49) | GCGRGIPRGLP1RALDH1A1MAPT | |
| SCHEMBL2650187 | 0.90 | GCGR (0.54) | GCGRGIPRGLP1RMAPTSMN1; SMN2 | |
| SCHEMBL6752839 | 0.90 | GCGR (0.49) | GCGRGIPRGLP1RSMN1; SMN2EPHX2 | |
| SCHEMBL2651224 | 0.90 | GCGR (0.49) | GCGRGIPRGLP1RALDH1A1LMNA | |
| SCHEMBL2651843 | 0.90 | GCGR (0.49) | GCGRGIPRGLP1RLMNAMAPT | |
| SCHEMBL2650113 | 0.90 | GCGR (0.57) | GCGRGIPRGLP1RALDH1A1MAPT | |
| SCHEMBL6750344 | 0.90 | GCGR (0.49) | GCGRGIPRGLP1RADCY6ADCY3 | |
| SCHEMBL6752430 | 0.89 | GCGR (0.47) | GCGRGIPRGLP1RALDH1A1LMNA | |
| SCHEMBL2650683 | 0.88 | GCGR (0.49) | GCGRGIPRGLP1RSMN1; SMN2ADCY6 | |
| SCHEMBL2651030 | 0.88 | GCGR (0.48) | GCGRGIPRGLP1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127560-A1 | Glucagon antagonists/inverse agonists | MADSEN PETER (DK) | 2004-07-01 | — | — | US | claimed |
| US-6706744-B2 | HYPOGLYCEMIC AGENTS; ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2004-03-16 | — | — | US | claimed |
| US-20030065031-A1 | Glucagon antagonists/inverse agonists | PFIZER INC | 2003-04-03 | — | — | US | claimed |
| WO-2002040444-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2002-05-23 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127560-A1 | Glucagon antagonists/inverse agonists | GLP1R, GPR119, GCGR | GCGR 3/4885GIPR 4/4885GLP1R 1/4885 |
| US-20030065031-A1 | Glucagon antagonists/inverse agonists | GLP1R, GPR119, GCGR | GCGR 3/4885GIPR 4/4885GLP1R 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.