Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.33 |
| ▸ | RELA | Q04206 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651299 | 0.86 | POLB (0.40) | SMN1; SMN2NPC1RAB9AMAPK14MAPT | |
| SCHEMBL1340704 | 0.84 | POLB (0.41) | SMN1; SMN2MAPK14MAPTPOLB | |
| SCHEMBL1340915 | 0.82 | POLB (0.42) | SMN1; SMN2NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL2650756 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL1344262 | 0.69 | POLB (0.45) | SMN1; SMN2PRNPMEN1MAPTKMT2A | |
| SCHEMBL1340838 | 0.68 | POLB (0.43) | SMN1; SMN2MAPK14MAPTPOLB | |
| SCHEMBL1341597 | 0.68 | MAPK14 (0.41) | SMN1; SMN2NPC1RAB9AMAPK14MEN1 | |
| SCHEMBL1340733 | 0.68 | POLB (0.39) | SMN1; SMN2MAPK14MAPTPOLB | |
| SCHEMBL1343546 | 0.68 | MAPK14 (0.39) | SMN1; SMN2MAPK14MAPTPOLB | |
| SCHEMBL2650977 | 0.68 | MAPK14 (0.36) | MAPK14POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |