Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10334624 | 0.84 | ESR1 (0.52) | GLAL3MBTL1ESR1FFAR1ALOX15 | |
| SCHEMBL9292114 | 0.80 | CYP2D6 (0.57) | GLAL3MBTL1ESR1FFAR1ACP3 | |
| SCHEMBL10334876 | 0.79 | ESR1 (0.46) | GLAL3MBTL1ESR1FFAR1ALOX15 | |
| SCHEMBL19067651 | 0.76 | PPARG (0.43) | GLAL3MBTL1ESR1FFAR1ACP3 | |
| SCHEMBL2652142 | 0.74 | ESR1 (0.42) | ESR1FFAR1KDM4ELMNACYP2D6 | |
| SCHEMBL2794839 | 0.72 | CTSA (0.49) | ACP3CTSA | |
| SCHEMBL9292031 | 0.71 | KDM4E (0.39) | GLAL3MBTL1FFAR1ALOX15KDM4E | |
| SCHEMBL6202860 | 0.71 | ESR1 (0.52) | L3MBTL1ESR1ALOX15ACP3KDM4E | |
| SCHEMBL30781885 | 0.71 | GABBR2 (0.48) | L3MBTL1ACP3POLBCTSANPSR1 | |
| SCHEMBL658439 | 0.71 | GABBR2 (0.48) | L3MBTL1ACP3POLBCTSANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404335-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | Astrazeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000267-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |