Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 14/20 | 0.56 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649782 | 0.83 | GCK (0.68) | GCKFFAR2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL4676850 | 0.82 | GCK (0.59) | GCKFFAR2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL2664673 | 0.79 | GCK (0.74) | GCKFFAR2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL2645294 | 0.78 | GCK (0.59) | GCKFFAR2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL2647391 | 0.77 | GCK (0.62) | GCKFFAR2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL2645222 | 0.77 | GCK (0.73) | GCKFFAR2KCNH2EPHX2 | |
| SCHEMBL2646466 | 0.76 | GCK (0.72) | GCKFFAR2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL4676853 | 0.76 | GCK (0.58) | GCKFFAR2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL2658630 | 0.76 | GCK (0.63) | GCKFFAR2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL2645352 | 0.76 | GCK (0.63) | GCKFFAR2KCNH2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283830-A1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-19 | — | — | EP | claimed |
| WO-2001085707-A1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-15 | — | — | WO | claimed |