Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649429 | 0.84 | GCK (0.70) | GCKKCNH2FFAR2CYP1A2CYP3A4 | |
| SCHEMBL4676850 | 0.83 | GCK (0.59) | GCKKCNH2FFAR2CYP1A2CYP3A4 | |
| SCHEMBL2647391 | 0.78 | GCK (0.62) | GCKKCNH2FFAR2CYP1A2CYP3A4 | |
| SCHEMBL2664673 | 0.77 | GCK (0.74) | GCKKCNH2FFAR2CYP1A2CYP3A4 | |
| SCHEMBL2649427 | 0.76 | GCK (0.76) | GCKKCNH2FFAR2CYP1A2CYP3A4 | |
| SCHEMBL2645294 | 0.76 | GCK (0.59) | GCKKCNH2FFAR2CYP1A2CYP3A4 | |
| SCHEMBL2649424 | 0.76 | GCK (0.72) | GCKKCNH2FFAR2CYP1A2CYP3A4 | |
| SCHEMBL2651627 | 0.76 | GCK (0.56) | GCKKCNH2FFAR2CYP1A2CYP3A4 | |
| SCHEMBL2647388 | 0.74 | GCK (0.79) | GCKKCNH2FFAR2CYP1A2CYP3A4 | |
| Ro-281675 SCHEMBL2646000 | 0.74 | GCK (1.00) | GCKKCNH2FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283830-B1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2008-06-18 | — | — | EP | claimed |