Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 9/20 | 0.68 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | SCN4A | P35499 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2645296 | 0.90 | GCK (0.72) | GCKFFAR2KCNH2HTTGAA | |
| SCHEMBL2650556 | 0.86 | GCK (0.62) | GCKFFAR2KCNH2HTTGAA | |
| SCHEMBL2650222 | 0.83 | GCK (0.79) | GCKFFAR2KCNH2 | |
| SCHEMBL2659396 | 0.82 | GCK (0.73) | GCKFFAR2KCNH2HTTGAA | |
| Ro-281675 SCHEMBL2646000 | 0.81 | GCK (1.00) | GCKFFAR2KCNH2 | |
| Ro-281675 SCHEMBL7089685 | 0.81 | GCK (1.00) | GCKFFAR2KCNH2 | |
| SCHEMBL2645678 | 0.81 | GCK (0.81) | GCKFFAR2KCNH2HTTMEN1 | |
| Ro-281675 SCHEMBL2645615 | 0.81 | GCK (1.00) | GCKFFAR2KCNH2 | |
| SCHEMBL2649424 | 0.81 | GCK (0.72) | GCKFFAR2KCNH2MEN1KMT2A | |
| SCHEMBL2650937 | 0.81 | GCK (0.69) | GCKFFAR2KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283830-B1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2008-06-18 | — | — | EP | claimed |
| CN-1185220-C | Para-substituted phenylamide glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-01-19 | — | — | CN | claimed |
| CN-1427830-A | Para-substituted phenylamide glucokinase activators | HOFFMANN LA ROCHE (CH) | 2003-07-02 | — | — | CN | claimed |
| US-20030060625-A1 | Para-amine substituted phenylamide glucokinase activators | BIZZARRO FRED THOMAS (US) | 2003-03-27 | — | — | US | claimed |
| EP-1283830-A1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-19 | — | — | EP | claimed |
| US-20010051731-A1 | Para-amine substituted phenylamide glucokinase activators | HOFFMANN-LA ROCHE INC. | 2001-12-13 | — | — | US | claimed |
| WO-2001085707-A1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-15 | — | — | WO | claimed |
| EP-1283830-B1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2008-06-18 | — | — | EP | disclosed |
| EP-1283830-B1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2008-06-18 | — | — | EP | disclosed |
| CN-1185220-C | Para-substituted phenylamide glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-01-19 | — | — | CN | disclosed |
| CN-1427830-A | Para-substituted phenylamide glucokinase activators | HOFFMANN LA ROCHE (CH) | 2003-07-02 | — | — | CN | disclosed |
| US-20030060625-A1 | Para-amine substituted phenylamide glucokinase activators | BIZZARRO FRED THOMAS (US) | 2003-03-27 | — | — | US | disclosed |
| EP-1283830-A1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-19 | — | — | EP | disclosed |
| US-6489485-B2 | INCREASES INSULIN SECRETION; TREATMENT OF TYPE II DIABETES | HOFFMANN-LA ROCHE INC. | 2002-12-03 | — | — | US | disclosed |
| US-20010051731-A1 | Para-amine substituted phenylamide glucokinase activators | HOFFMANN-LA ROCHE INC. | 2001-12-13 | — | — | US | disclosed |
| WO-2001085707-A1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-15 | — | — | WO | disclosed |
| WO-2001085707-A1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010051731-A1 | Para-amine substituted phenylamide glucokinase activators | GCKR, GCK, PDXK | GCK 2/4885FFAR2 1016/4885KCNH2 478/4885 |
| US-20030060625-A1 | Para-amine substituted phenylamide glucokinase activators | GCKR, GCK, PDXK | GCK 2/4885FFAR2 1016/4885KCNH2 478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.