Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.64 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27084150 | 0.89 | KRAS (0.52) | KRASMAPK3MAPK1 | |
| SCHEMBL31531797 | 0.88 | KRAS (0.50) | KRAS | |
| SCHEMBL31531798 | 0.88 | KRAS (0.50) | KRAS | |
| SCHEMBL31531758 | 0.87 | KRAS (0.50) | KRAS | |
| SCHEMBL31531812 | 0.87 | KRAS (0.50) | KRAS | |
| SCHEMBL26517489 | 0.86 | KRAS (0.56) | KRASMAPK3MAPK1 | |
| SCHEMBL26539587 | 0.86 | KRAS (0.49) | KRASMAPK3MAPK1 | |
| SCHEMBL31242530 | 0.86 | KRAS (0.58) | KRASMAPK3MAPK1 | |
| SCHEMBL26543484 | 0.85 | KRAS (0.52) | KRAS | |
| SCHEMBL31170176 | 0.85 | KRAS (0.74) | KRASMAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043451-A1 | KRAS INHIBITORS | ELI LILLY AND COMPANY | 2024-02-08 | — | — | US | disclosed |
| WO-2023183585-A1 | KRAS INHIBITORS | ELI LILLY AND COMPANY (US) | 2023-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240043451-A1 | KRAS INHIBITORS | KRAS, NRAS, HRAS | KRAS 1/4885MAPK3 329/4885MAPK1 299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.