Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | RHOC | P08134 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653962 | 0.91 | MEN1 (0.58) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2653250 | 0.88 | MEN1 (0.57) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2652734 | 0.88 | MEN1 (0.57) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2653990 | 0.87 | MEN1 (0.56) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2654466 | 0.87 | MEN1 (0.56) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2652593 | 0.87 | MEN1 (0.57) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2653326 | 0.87 | MEN1 (0.57) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2651645 | 0.84 | PPARD (0.48) | MAPTSMN1; SMN2EPHX2PPARG | |
| SCHEMBL2651906 | 0.84 | MEN1 (0.56) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2655721 | 0.84 | MEN1 (0.56) | MAPTSMN1; SMN2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |