Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 10/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | ESRRG | P62508 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653259 | 0.92 | PPARD (0.50) | PPARDPPARGPPARAEPHX2CNR2 | |
| SCHEMBL2652102 | 0.89 | PPARD (0.49) | PPARDPPARGPPARAEPHX2CNR2 | |
| SCHEMBL2651863 | 0.84 | MAPT (0.57) | PPARGEPHX2MAPTSMN1; SMN2 | |
| SCHEMBL2652464 | 0.84 | PPARD (0.44) | PPARDPPARGPPARACNR2MAPT | |
| SCHEMBL2652659 | 0.83 | PPARD (0.52) | PPARDPPARGPPARAROCK2ROCK1 | |
| SCHEMBL2652487 | 0.80 | PPARD (0.45) | PPARDPPARGPPARAMAPTLMNA | |
| SCHEMBL2654466 | 0.79 | MEN1 (0.56) | MAPTTP53ROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL2653990 | 0.79 | MEN1 (0.56) | MAPTTP53ROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL2271647 | 0.79 | GCG (0.51) | — | |
| SCHEMBL2655041 | 0.79 | PPARD (0.50) | PPARDPPARGPPARAEPHX2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |