Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL158186 | 0.93 | NAPRT (0.53) | SMN1; SMN2POLBPKML3MBTL1GAA | |
| SCHEMBL29552438 | 0.86 | MAPK1 (0.65) | MAPK1SMN1; SMN2POLBPKML3MBTL1 | |
| SCHEMBL64640 | 0.86 | MAPK1 (0.65) | MAPK1SMN1; SMN2POLBPKML3MBTL1 | |
| SCHEMBL29776105 | 0.85 | MAPK1 (0.62) | MAPK1SMN1; SMN2POLBPKML3MBTL1 | |
| SCHEMBL20241211 | 0.85 | MAPK1 (0.62) | MAPK1SMN1; SMN2POLBPKML3MBTL1 | |
| SCHEMBL3456483 | 0.81 | MAPK1 (0.68) | MAPK1L3MBTL1KDM4ERAB9AMAPT | |
| SCHEMBL2660622 | 0.78 | HSD17B3 (0.43) | POLBPKML3MBTL1NAPRTRAB9A | |
| SCHEMBL1765450 | 0.78 | MLYCD (0.56) | MAPK1SMN1; SMN2L3MBTL1KDM4EGAA | |
| SCHEMBL31606802 | 0.76 | NAPRT (0.60) | SMN1; SMN2POLBPKML3MBTL1GAA | |
| SCHEMBL333999 | 0.76 | NAPRT (0.60) | SMN1; SMN2POLBPKML3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |