Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 20/20 | 0.58 |
| ▸ | GIPR | P48546 | 7/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651583 | 0.92 | GCGR (0.49) | GCGRGIPR | |
| SCHEMBL2653041 | 0.92 | GCGR (0.49) | GCGRGIPR | |
| SCHEMBL2652475 | 0.92 | GCGR (0.49) | GCGRGIPR | |
| SCHEMBL2651638 | 0.92 | GCGR (0.49) | GCGRGIPR | |
| SCHEMBL2652203 | 0.91 | GCGR (0.50) | GCGRGIPR | |
| SCHEMBL2653154 | 0.90 | GCG (0.53) | GCGR | |
| SCHEMBL2651753 | 0.90 | GCG (0.49) | GCGR | |
| SCHEMBL2654517 | 0.90 | GCGR (0.57) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2655109 | 0.90 | GCGR (0.57) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2650861 | 0.89 | GCGR (0.46) | GCGRGIPRCYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | claimed |
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |