Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.52 |
| ▸ | NPY5R | Q15761 | 18/20 | 0.51 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4161263 | 0.82 | NPY5R (0.76) | NPY5R | |
| SCHEMBL4041697 | 0.80 | NPY5R (0.50) | DGAT1NPY5R | |
| SCHEMBL4047630 | 0.79 | NPY5R (0.53) | DGAT1NPY5R | |
| SCHEMBL4046249 | 0.77 | NPY5R (0.55) | DGAT1NPY5R | |
| SCHEMBL4045480 | 0.74 | DGAT1 (0.49) | DGAT1NPY5R | |
| SCHEMBL4044645 | 0.73 | NPY5R (0.51) | DGAT1NPY5R | |
| SCHEMBL4042301 | 0.71 | NPY5R (0.56) | NPY5RTNKSTNKS2 | |
| SCHEMBL4047098 | 0.70 | DGAT1 (0.49) | DGAT1NPY5R | |
| SCHEMBL4047958 | 0.70 | DGAT1 (0.45) | DGAT1NPY5R | |
| SCHEMBL15070803 | 0.70 | NPY5R (0.54) | NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635832-A2 | COMBINATION THERAPY FOR THE TREATMENT OF DIABETES | Merck & Co., Inc. (US) | 2006-03-22 | — | — | EP | claimed |
| WO-2004110375-A2 | COMBINATION THERAPY FOR THE TREATMENT OF DIABETES | MERCK & CO., INC. (US) | 2004-12-23 | — | — | WO | claimed |
| EP-1635773-A2 | COMBINATION THERAPY FOR THE TREATMENT OF HYPERTENSION | Merck & Co., Inc. (a New Jersey corp.) (US) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004110368-A2 | COMBINATION THERAPY FOR THE TREATMENT OF HYPERTENSION | MERCK & CO., INC. (US) | 2004-12-23 | — | — | WO | disclosed |