Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 16/20 | 0.66 |
| ▸ | GABRB3 | P28472 | 16/20 | 0.66 |
| ▸ | GABRA5 | P31644 | 16/20 | 0.66 |
| ▸ | GABRA3 | P34903 | 16/20 | 0.66 |
| ▸ | GABRA1 | P14867 | 12/20 | 0.66 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.66 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652803 | 0.94 | GABRG2 (0.74) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2652914 | 0.83 | GABRG2 (0.74) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2653173 | 0.81 | GABRG2 (0.86) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2653096 | 0.80 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2652718 | 0.78 | GABRG2 (0.86) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2652324 | 0.78 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2652390 | 0.78 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2651943 | 0.78 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2652434 | 0.78 | GABRG2 (0.84) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2652023 | 0.78 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532120-A1 | PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004014865-A1 | PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2004-02-19 | — | — | WO | disclosed |