SCHEMBL26523922

SCHEMBL26523922

O=C1NCc2cc(F)ccc2-c2ccc(Br)cc21

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 5/20 0.51
PARP10 Q53GL7 4/20 0.46
PARP1 P09874 2/20 0.46
PARP11 Q9NR21 2/20 0.46
CLK4 Q9HAZ1 2/20 0.43
DAPK3 O43293 1/20 0.43
NTRK1 P04629 1/20 0.43
PIM1 P11309 1/20 0.43
FLT3 P36888 1/20 0.43
GSK3B P49841 1/20 0.43
ROCK1 Q13464 1/20 0.43
S100A4 P26447 1/20 0.42
AKR1A1 P14550 1/20 0.40
AKR1B1 P15121 1/20 0.40
TDP2 O95551 1/20 0.40
CA12 O43570 1/20 0.39
CA9 Q16790 1/20 0.39
GRM2 Q14416 1/20 0.38
PTPRC P08575 1/20 0.38
FABP6 P51161 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL164795 0.84 GRM5 (0.68) GRM5PARP10PARP1PARP11CLK4
SCHEMBL30545957 0.84 GRM5 (0.68) GRM5PARP10PARP1PARP11CLK4
SCHEMBL275805 0.80 PARP10 (0.68) GRM5PARP10PARP1PARP11CLK4
SCHEMBL391991 0.77 PARP10 (0.68) PARP10PARP1PARP11CLK4NTRK1
SCHEMBL29506974 0.77 PARP10 (0.68) PARP10PARP1PARP11CLK4NTRK1
SCHEMBL9475799 0.73 PARP1 (0.68) GRM5PARP10PARP1CLK4DAPK3
SCHEMBL30524061 0.73 PARP1 (0.68) GRM5PARP10PARP1CLK4DAPK3
SCHEMBL29853505 0.72 CA9 (0.44) GRM5PARP1CLK4DAPK3NTRK1
SCHEMBL26775387 0.72 CA9 (0.44) GRM5PARP1CLK4DAPK3NTRK1
SCHEMBL28040154 0.71 METAP1 (0.47) PARP10PARP1PARP11AKR1A1AKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4257588-A1 SMALL MOLECULE INHIBITOR OF CATHEPSIN C AND MEDICINAL USE THEREOF Reistone Biopharma Company Limited (CN) 2023-10-11 EP disclosed