Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 7/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | PTAFR | P25105 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652487 | 0.92 | PPARD (0.45) | PPARDROCK2ROCK1MAPTLMNA | |
| SCHEMBL2651240 | 0.88 | MAPT (0.48) | ROCK2ROCK1MAPTTP53SMN1; SMN2 | |
| SCHEMBL2652459 | 0.87 | SMN1; SMN2 (0.52) | PPARDMAPTLMNATP53PPARA | |
| SCHEMBL2654487 | 0.85 | MEN1 (0.48) | ROCK2ROCK1MAPTTP53SMN1; SMN2 | |
| SCHEMBL2662329 | 0.85 | MEN1 (0.49) | ROCK2ROCK1MAPTTP53PPARA | |
| SCHEMBL2652924 | 0.85 | SMN1; SMN2 (0.53) | PPARDMAPTTP53PPARASMN1; SMN2 | |
| SCHEMBL2651645 | 0.84 | PPARD (0.48) | PPARDROCK2ROCK1MAPTLMNA | |
| SCHEMBL2653664 | 0.83 | MEN1 (0.48) | PPARDROCK2ROCK1MAPTTP53 | |
| SCHEMBL2652938 | 0.82 | MEN1 (0.48) | PPARDROCK2ROCK1MAPTTP53 | |
| SCHEMBL2652102 | 0.82 | PPARD (0.49) | PPARDROCK2ROCK1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |