Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 3/20 | 0.34 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655511 | 0.99 | HPGD (0.40) | HPGDACKR3MEN1KMT2AMAPT | |
| SCHEMBL2653247 | 0.97 | HPGD (0.39) | HPGDACKR3MEN1KMT2AMAPT | |
| SCHEMBL2656127 | 0.93 | GCGR (0.41) | ACKR3KMT2AMAPTPPARGPPARA | |
| SCHEMBL2653567 | 0.92 | PPARD (0.41) | HPGDMEN1KMT2AMAPTPPARG | |
| SCHEMBL2656490 | 0.92 | GCGR (0.41) | ACKR3KMT2AMAPTPPARGPPARA | |
| SCHEMBL2654307 | 0.90 | HPGD (0.43) | HPGDACKR3MEN1KMT2AMAPT | |
| SCHEMBL2654407 | 0.89 | GCGR (0.42) | ACKR3KMT2AMAPTPPARGPPARA | |
| SCHEMBL2652386 | 0.89 | GCGR (0.42) | HPGDACKR3MEN1KMT2AMAPT | |
| SCHEMBL2653812 | 0.86 | GCGR (0.42) | HPGDACKR3MEN1KMT2AMAPT | |
| SCHEMBL2655313 | 0.85 | GCGR (0.45) | PPARGPPARAGCGRPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |