Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 9/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | PPARA | Q07869 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 3/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654749 | 0.93 | GCGR (0.46) | PPARDPPARGPPARAGCGR | |
| SCHEMBL2655511 | 0.93 | HPGD (0.40) | PPARDPPARGPPARAHPGDGCGR | |
| SCHEMBL2652528 | 0.92 | HPGD (0.42) | PPARDPPARGPPARAHPGDGCGR | |
| SCHEMBL2655313 | 0.92 | GCGR (0.45) | PPARDPPARGPPARAGCGR | |
| SCHEMBL2653083 | 0.90 | HPGD (0.41) | PPARDPPARGPPARAHPGDGCGR | |
| SCHEMBL2653247 | 0.90 | HPGD (0.39) | PPARDPPARGPPARAHPGDGCGR | |
| SCHEMBL2654424 | 0.90 | GCGR (0.46) | PPARDPPARGPPARAGCGR | |
| SCHEMBL9072397 | 0.90 | PPARD (0.41) | PPARDPPARGPPARAGCGR | |
| SCHEMBL2652772 | 0.89 | HPGD (0.42) | PPARDPPARGPPARAHPGDGCGR | |
| SCHEMBL2653431 | 0.89 | HPGD (0.47) | PPARDPPARGPPARAHPGDNOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |