Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | CTSV | O60911 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7491879 | 0.81 | PARP1 (0.62) | ABCB1NPC1KMT2AMEN1MAPT | |
| SCHEMBL8554782 | 0.77 | ABCB1 (0.72) | ABCB1NPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL10651902 | 0.74 | SIRT2 (0.51) | ABCB1NPC1KMT2AMEN1MAPT | |
| SCHEMBL27730417 | 0.72 | MAPT (0.48) | ABCB1NPC1KMT2AMEN1MAPT | |
| SCHEMBL28484392 | 0.72 | CHUK (0.67) | NPC1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL30455197 | 0.72 | PARP1 (0.68) | NPC1KMT2AMAPTALDH1A1L3MBTL1 | |
| SCHEMBL1135541 | 0.72 | PARP1 (0.68) | NPC1KMT2AMAPTALDH1A1L3MBTL1 | |
| SCHEMBL3416713 | 0.72 | SMN1; SMN2 (0.45) | NPC1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL17950637 | 0.72 | MEN1 (0.51) | NPC1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL26164139 | 0.71 | PARP1 (0.71) | NPC1KMT2AMAPTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0616807-B1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH AS (DK) | 1998-07-08 | — | — | EP | disclosed |
| US-5554632-A | CENTRAL NERVOUS SYSTEM | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| US-5554630-A | TREATING ANXIETY, CONVULSIONS AND SLEEP DISORDERS IN LIVING ANIMALS BY MODULATION OF THE BENZODIAZEPINE RECEPTOR OF THE CENTRAL NERVOUS SYSTEM WITH 1-/3-HETEROCYCLYLPHENYL/-BENZIMIDAZOLES | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| EP-0616807-A1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH A/S (DK) | 1994-09-28 | — | — | EP | disclosed |